Research papers

Pipette

The information on this website is based on published scientific research. Some of the papers listed below are available on the Internet – search Google for the authors' names and/or the title of the paper or search the PubMed database.

Abedin P, Weaver JB, Egginton E. Intrahepatic cholestasis of pregnancy: prevalence and ethnic distribution. Ethn Health 1999; 4: 35–37

Al Inizi S, Gupta R, Gale A. Fetal tachyarrhythmia with atrial flutter in obstetric cholestasis. Int J Gynaecol Obstet 2006; 93: 53–54

Alsulyman OM, Ouzounian JG, Ames-Castro M, Goodwin TM. Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol 1996; 175: 957–960

Altshuler G, Hyde S. Meconium-induced vasocontraction: a potential cause of cerebral and other fetal hypoperfusion and of poor pregnancy outcome. J Child Neurol 1989; 4: 137–142

Ammälä P, Kariniemi V. Short-term variability of fetal heart rate in cholestasis of pregnancy. Am J Obstet Gynecol 1981; 141: 217–220

Arrese M, Reyes H. Intrahepatic cholestasis of pregnancy: a past and present riddle. Ann Hepatol 2006; 5: 202–205

Atabey S, Duvan CI, Eren U, Turhan NO. Intrahepatic cholestasis and eclampsia: a case report. Hypertens Pregnancy 2007; 26: 363–369

Aytaç S, Kargili A, Türkay C. A prolonged gestational intrahepatic cholestasis: a case report. Turk J Gastroenterol 2006; 17: 206–208

Azzaroli F, Mennone A, Feletti V, Simoni P, Baglivo E, Montagnani M, Rizzo N, Pelusi G, DE Aloysio D, Lodato F, Festi D, Colecchia A, Roda E, Boyer JL, Mazzella G. Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Aliment Pharmacol Ther 2007; 26: 1139–1146

Bachs L, Parés A, Elena M, Piera C, Rodés J. Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. Lancet 1989; 1: 574–576

Bacq Y, Myara A, Brechot MC, Hamon C, Studer E, Trivin F, Metman EH. Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. J Hepatol 1995; 22: 66–70

Bacq Y, Sapey T, Bréchot MC, Pierre F, Fignon A, Dubois F. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997; 26: 358–364

Bacq Y, Zarka O, Bréchot JF, Mariotte N, Vol S, Tichet J, Weill J. Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls. Hepatology 1996; 23: 1030–1034

Barth A, Klinger G, Rost M. Influence of ethinyloestradiol propanolsulphonate on serum bile acids in healthy volunteers. Exp Toxicol Pathol 2003; 54: 381–386

Beckett GJ, Hayes JD. Glutathione S-transferases: biomedical applications. Adv Clin Chem 1993; 30: 281–380

Benifla JL, Dumont M, Levardon M, Foucher E, Cadiot G, Crenn-Hebert C, Heid M, Lelaidier C, Rosenbaum A, Bernuau J, Erlinger S, Frydman R, Madelenat P. [Effects of micronized natural progesterone on the liver during the third trimester of pregnancy] Contracept Fertil Sex 1997; 25: 165–169

Berg B, Helm G, Petersohn L, Tryding N. Cholestasis of pregnancy. Clinical and laboratory studies. Acta Obstet Gynecol Scand 1986; 65: 107–113

Berkane N, Cocheton JJ, Brehier D, Merviel P, Wolf C, Lefèvre G, Uzan S. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. A retrospective study of 19 cases. Acta Obstet Gynecol Scand 2000; 79: 941–946

Bloom SL, Sheffield JS, McIntire DD, Leveno KJ. Antenatal dexamethasone and decreased birth weight. Obstet Gynecol 2001; 97: 485–490

Boelsterli UA, Rakhit G, Balazs T. Modulation by S-adenosyl-L-methionine of hepatic Na+,K+-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis. Hepatology 1983; 3: 12–17

Bonfirraro G, Chieffi O, Quinti R, Tedesco R, LeGrazie C, Bortolini M. S-adenosyl-L-methionine (SAMe)-induced amelioration of intrahepatic cholestasis of pregnancy. Results of an open study. Drug Invest 1990; 2: 125–128

Brites D, El-Mir MY, Oliveira N, Marín JJG. Amniotic fluid bile acid changes in the course of ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy [Abstract]. J Hepatol 1997; 26: 164A

Brites D, El-Mir MY, Rodrigues CMP, van-Zeller H, Marín JJG. Bile acid composition of amniotic fluid and maternal serum in cholestasis of pregnancy and effect of ursodeoxycholic acid [Abstract]. J Hepatol 1998; 28: 125A

Brites D, Rodrigues CM. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comments] J Hepatol 1998; 29: 743–751

Brites D, Rodrigues CM, Oliveira N, Cardoso M, Graça LM. Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy. J Hepatol 1998; 28: 91–98

Brites D, Rodrigues CM, van-Zeller H, Brito A, Silva R. Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal. Eur J Obstet Gynecol Reprod Biol 1998; 80: 31–38

Brown ES. Aspiration and lung surfactant. Anesth Analg 1967; 46: 665–672

Campos GA, Castillo RJ, Toro FG. [Effect of bile acids on the myometral contractility of the isolated pregnant uterus] Rev Chil Obstet Ginecol 1988; 53: 229–233

Campos GA, Guerra FA, Israel EJ. Effects of cholic acid infusion in fetal lambs. Acta Obstet Gynecol Scand 1986; 65: 23–26

Carter J. Serum bile acids in normal pregnancy. Br J Obstet Gynaecol 1991; 98: 540–543

Castaño G, Lucangioli S, Sookoian S, Mesquida M, Lemberg A, Di Scala M, Franchi P, Carducci C, Tripodi V. Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy. Clin Sci (Lond) 2006; 110: 459–465

Colombo C, Roda A, Roda E, Buscaglia M, dell'Agnola CA, Filippetti P, Ronchi M, Sereni F. Correlation between fetal and maternal serum bile acid concentrations. Pediatr Res 1985; 19: 227–231

Costoya AL, Leontic EA, Rosenberg HG, Delgado MA. Morphological study of placental terminal villi in intrahepatic cholestasis of pregnancy: histochemistry, light and electron microscopy. Placenta 1980; 1: 361–368

Crocenzi FA, Mottino AD, Cao J, Veggi LM, Pozzi EJ, Vore M, Coleman R, Roma MG. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Am J Physiol Gastrointest Liver Physiol 2003; 285: G449–G459

Dann AT, Kenyon AP, Wierzbicki AS, Seed PT, Shennan AH, Tribe RM. Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy. Obstet Gynecol 2006; 107: 106–114

Dann AT, Kenyon AP, Seed PT, Poston L, Shennan AH, Tribe RM. Glutathione S-transferase and liver function in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology 2004; 40: 1406–1414

Davies MH, da Silva RC, Jones SR, Weaver JB, Elias E. Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995; 37: 580–584

de Vree JM, Jacquemin E, Sturm E, Cresteil D, Bosma PJ, Aten J, Deleuze JF, Desrochers M, Burdelski M, Bernard O, Oude Elferink RP, Hadchouel M. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci USA 1998; 95: 282–287

Diac M, Kenyon A, Nelson-Piercy C, Girling J, Cheng F, Tribe RM, Goodman J, Shennan A, Williamson C. Dexamethasone in the treatment of obstetric cholestasis: a case series. J Obstet Gynaecol 2006; 26: 110–114

Diaferia A, Nicastri PL, Tartagni M, Loizzi P, Iacovizzi C, Di Leo A. Ursodeoxycholic acid therapy in pregnant women with cholestasis. Int J Gynaecol Obstet 1996; 52: 133–140

Dixon PH, van Mil SW, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore GE, Linton KJ, Williamson C. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut 2009; 58: 537–544

Dixon PH, Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C, de Swiet M, Warnes G, Elias E, Higgins CF, Johnston DG, McCarthy MI, Williamson C. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet 2000; 9: 1209–1217

Dixon PH, Williamson C. The molecular genetics of intrahepatic cholestasis of pregnancy. Obstet Med 2008; 1: 65–71

Dong M, Xie X, Wang Z, He J, Zhou J, Cheng Q. Impaired mixed lymphocyte reaction in intrahepatic cholestasis of pregnancy. Gynecol Obstet Invest 2002; 54: 191–195

Eliakim M, Sadovsky E, Stein O, Shenkar YG. Recurrent cholestatic jaundice of pregnancy. Report of five cases and electron microscopic observations. Arch Intern Med 1966; 117: 696–705

Eloranta ML, Häkli T, Hiltunen M, Helisalmi S, Punnonen K, Heinonen S. Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. Scand J Gastroenterol 2003; 38: 648–652

Eloranta ML, Heinonen S, Mononen T, Saarikoski S. Risk of obstetric cholestasis in sisters of index patients. Clin Genet 2001; 60: 42–45

Eloranta ML, Heinonen S, Kirkinen P. Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG. Acta Obstet Gynecol Scand 2000; 79: 548–552

Eloranta ML, Heiskanen JT, Hiltunen MJ, Mannermaa AJ, Punnonen KR, Heinonen ST. Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alpha gene polymorphisms in Finnish women with obstetric cholestasis. Eur J Obstet Gynecol Reprod Biol 2002; 105: 132–135

Falconer JD, Smith AN, Eastwood MA. The effects of bile acids on colonic motility in the rabbit. Q J Exp Physiol Cogn Med Sci 1980; 65: 135–144

Fisk NM, Bye WB, Storey GN. Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital. Aust N Z J Obstet Gynaecol 1988; 28: 172–176

Fisk NM, Storey GN. Fetal outcome in obstetric cholestasis. Br J Obstet Gynaecol 1988; 95: 1137–1143

Floreani A, Carderi I, Paternoster D, Soardo G, Azzaroli F, Esposito W, Variola A, Tommasi AM, Marchesoni D, Braghin C, Mazzella G. Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations. Aliment Pharmacol Ther 2006; 23: 1649–1653

Floreani A, Carderi I, Paternoster D, Soardo G, Azzaroli F, Esposito W, Montagnani M, Marchesoni D, Variola A, Rosa Rizzotto E, Braghin C, Mazzella G. Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. Dig Liver Dis 2008; 40: 366–370

Floreani A, Paternoster D, Grella V, Sacco S, Gangemi M, Chiaramonte M. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol 1994; 101: 64–65

Frezza M, Centini G, Cammareri G, Le Grazie C, Di Padova C. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990; 37 Suppl 2: 122–125

Frezza M, Pozzato G, Chiesa L, Stramentinoli G, di Padova C. Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine administration. Hepatology 1984; 4: 274–278

Frezza M, Tritapepe R, Pozzato G, Di Padova C. Prevention of S-adenosylmethionine of estrogen-induced hepatobiliary toxicity in susceptible women. Am J Gastroenterol 1988; 83: 1098–1102

Fulton IC, Douglas JG, Hutchon DJ, Beckett GJ. Is normal pregnancy cholestatic? Clin Chim Acta 1983; 130: 171–176

Furhoff AK. Itching in pregnancy. A 15-year follow-up study. Acta Med Scand 1974; 196: 403–410

Garoff L. Prediction of fetal outcome by urinary estriol, maternal serum placental lactogen, and alpha-fetoprotein in diabetes and hepatosis of pregnancy. Obstet Gynecol 1976; 48: 659–666

Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol 2009; 15(17): 2049–2066

Geier A, Dietrich CG, Gerloff T, Haendly J, Kullak-Ublick GA, Stieger B, Meier PJ, Matern S, Gartung C. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Biochim Biophys Acta 2003; 1609: 87–94

Gendrot C, Bacq Y, Brechot MC, Lansac J, Andres C. A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy. J Med Genet 2003; 40: e32

Germain AM, Kato S, Carvajal JA, Valenzuela GJ, Valdes GL, Glasinovic JC. Bile acids increase response and expression of human myometrial oxytocin receptor. Am J Obstet Gynecol 2003; 189: 577–582

Ghent CN, Bloomer JR, Klatskin G. Elevations in skin tissue levels of bile acids in human cholestasis: relation to serum levels and topruritus. Gastroenterology 1977; 73: 1125–1130

Girling JC, Dow E, Smith JH. Liver function tests in preeclampsia: importance of comparison with a reference range derived for normal pregnancy. Br J Obstet Gynaecol 1997; 104: 246–250

Glantz A, Marschall HU, Lammert F, Mattsson LA. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology 2005; 42: 1399–1405

Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Hepatology 2004; 40: 467–474

Glantz A, Reilly SJ, Benthin L, Lammert F, Mattsson LA, Marschall HU. Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine. Hepatology 2008; 47: 544–551

Gonzalez MC, Reyes H, Arrese M, Figueroa D, Lorca B, Andresen M, Segovia N, Molina C, Arce S. Intrahepatic cholestasis of pregnancy in twin pregnancies. J Hepatol 1989; 9: 84–90

Gorelik J, Shevchuk AI, Diakonov I, de Swiet M, Lab M, Korchev Y, Williamson C. Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic e f f e c t of taurocholat e in an in vi t ro s tudy of rat cardiomyocytes. BJOG 2003; 110: 467–474

Goulis DG, Walker IA, de Swiet M, Redman CW, Williamson C. Preeclampsia with abnormal liver function tests is associated with cholestasis in a subgroup of cases. Hypertens Pregnancy 2004; 23: 19–27

Gylling H, Riikonen S, Nikkilä K, Savonius H, Miettinen TA. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. Eur J Clin Invest 1998; 28: 359–363

Hayes PC, Hussey AJ, Keating J, Bouchier IA, Williams R, Beckett GJ, Hayes JD. Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase. Clin Chim Acta 1988; 172: 211–216

Heikinheimo M, Unnérus HA, Ranta T, Jalanko H, Seppälä M. Pregnancy-specific beta-1-glycoprotein levels in cholestasis of pregnancy. Obstet Gynecol 1978; 52: 276–278

Heikkinen J. Effect of a standard test meal on serum bile acid levels in healthy nonpregnant and pregnant women and in patients with intrahepatic cholestasis of pregnancy. Ann Clin Res 1983; 15: 183–188

Heikkinen J, Mäentausta O, Ylöstalo P, Jänne O. Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. Eur J Obstet Gynecol Reprod Biol 1982; 14: 153–162

Heikkinen J, Mäentausta O, Ylöstalo P, Jänne O. Changes in serum bile acid concentrations during normal pregnancy, in patients with intrahepatic cholestasis of pregnancy and in pregnant women with itching. Br J Obstet Gynaecol 1981; 88: 240–245

Heikkinen J. Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy. Obstet Gynecol 1983; 61: 581–587

Heinonen S, Kirkinen P. Pregnancy outcome with intrahepatic cholestasis. Obstet Gynecol 1999; 94: 189–193

Hirvioja ML, Tuimala R, Vuori J. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. Br J Obstet Gynaecol 1992; 99: 109–111

Hoensch HP, Balzer K, Dylewizc P, Kirch W, Goebell H, Ohnhaus EE. Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis. Eur J Clin Pharmacol 1985; 28: 475–477

Ikonen E. Jaundice in Late Pregnancy. Acta Obstet Gynecol Scand 1964; 43 Suppl 5: 1–130

Israel EJ, Guzman ML, Campos GA. Maximal response to oxytocin of the isolated myometrium from pregnant patients with intrahepatic cholestasis. Acta Obstet Gynecol Scand 1986; 65: 581–582

Jacquemin E, Cresteil D, Manouvrier S, Boute O, Hadchouel M. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet 1999; 353: 210–211

Jiang ZH, Qiu ZD, Liu WW, Liu YH, Wang QN, Miao HZ, Zhou ZC, Wu XL, Xu BY, Gu CH. Intrahepatic cholestasis of pregnancy and its complications. Analysis of 100 cases in area. Chin Med J (Engl) 1986; 99: 957–960

Johnson P, Samsioe G, Gustafson A. Studies in cholestasis of pregnancy. I. Clinical aspects and liver function tests. Acta Obstet Gynecol Scand 1975; 54: 77–84

Johnson P. Studies in cholestasis of pregnancy with special reference to lipids and lipoproteins. Acta Obstet Gynecol Scand Suppl 1973; 27: 1–80

Johnston WG, Baskett TF. Obstetric cholestasis. A 14 year review. Am J Obstet Gynecol 1979; 133: 299–301

Joutsiniemi T, Leino R, Timonen S, Pulkki K, Ekblad U. Hepatocellular enzyme glutathione S-transferase alpha and intrahepatic cholestasis of pregnancy. Acta Obstet Gynecol Scand 2008; 87: 1280–1284

Kaaja RJ, Kontula KK, Räihä A, Laatikainen T. Treatment of cholestasis of pregnancy with peroral activated charcoal. A preliminary study. Scand J Gastroenterol 1994; 29: 178–181

Kaneko T, Sato T, Katsuya H, Miyauchi Y. Surfactant therapy for pulmonary edema due to intratracheally injected bile acid. Crit Care Med 1990; 18: 77–83

Kater RM, Mistilis SP. Obstetric cholestasis and pruritus of pregnancy. Med J Aust 1967; 1: 638–640

Kauppila A, Jouppila P, Karvonen P, Tuimala R, Ylikorkala O. Effect of dexamethasone on blood levels of ACTH, cortisol, progesterone, estradiol and estriol during late pregnancy. Int J Gynaecol Obstet 1976; 14: 177–181

Kauppila A, Korpela H, Mäkilä UM, Yrjänheikki E. Low serum selenium concentration and glutathione peroxidase activity in intrahepatic cholestasis of pregnancy. Br Med J (Clin Res Ed) 1987; 294: 150–152

Kauppila A, Tuimala R, Ylikorkala O, Reinilä M, Ylöstalo P. Placental steroid synthesis from DHEAS during dexamethasone therapy. Obstet Gynecol 1979; 54: 39–42

Keitel V, Vogt C, Häussinger D, Kubitz R. Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology 2006; 131: 624–629

Kenyon AP, Piercy CN, Girling J, Williamson C, Tribe RM, Shennan AH. Obstetric cholestasis, outcome with active management: a series of 70 cases. BJOG 2002; 109: 282–288

Kenyon AP, Piercy CN, Girling J, Williamson C, Tribe RM, Shennan AH. Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis. BJOG 2001; 108: 1190–1192

Kiilholma P. Serum copper and zinc concentrations in intrahepatic cholestasis of pregnancy: a controlled study. Eur J Obstet Gynecol Reprod Biol 1986; 21: 207–212

Kirby J, Heaton KW, Burton JL. Pruritic effect of bile salts. Br Med J 1974; 4: 693–695

Kirkinen P, Ylöstalo P, Heikkinen J, Mäentausta O. Gallbladder function and maternal bile acids in intrahepatic cholestasis of pregnancy. Eur J Obstet Gynecol Reprod Biol 1984; 18: 29–34

Kirwan WO, Smith AN, Mitchell WD, Falconer JD, Eastwood MA. Bile acids and colonic motility in the rabbit and the human. Gut 1975; 16: 894–902

Knapen MF, Peters WH, Mulder TP, Steegers EA. A marker for hepatocellular damage. Lancet 2000; 355: 1463–1464

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Laatikainen TJ. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Am J Obstet Gynecol 1975; 122: 852–856

Laatikainen T, Ikonen E. Fetal prognosis in obstetric hepatosis. Ann Chir Gynaecol Fenn 1975; 64: 155–164

Laatikainen T, Ikonen E. Serum bile acids in cholestasis of pregnancy. Obstet Gynecol 1977; 50: 313–318

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Laatikainen T. Postprandial serum bile acids in cholestasis of pregnancy. Ann Clin Res 1978; 10: 307–312

Laatikainen T, Tulenheimo A. Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy. Int J Gynaecol Obstet 1984; 22: 91–94

Laifer SA, Stiller RJ, Siddiqui DS, Dunston-Boone G, Whetham JC. Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy. J Matern Fetal Med 2001; 10: 131–135

Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C. Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with druginduced liver injury. Pharmacogenet Genomics 2007; 17: 47–60

Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J Hepatol 2001; 35: 134–146

Lee RH, Goodwin TM, Greenspoon J, Incerpi M. The prevalence of intrahepatic cholestasis of pregnancy in a primarily Latina Los Angeles population. J Perinatol 2006; 26: 527–532

Lee RH, Kwok KM, Ingles S, Wilson ML, Mullin P, Incerpi M, Pathak B, Goodwin TM. Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy. Am J Perinatol 2008; 25: 341–345

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Lucena JF, Herrero JI, Quiroga J, Sangro B, Garcia-Foncillas J, Zabalegui N, Sola J, Herraiz M, Medina JF, Prieto J. A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. Gastroenterology 2003; 124: 1037–1042

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Marschall HU, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold J, Silbert D, Fuchsbichler A, Benthin L, Grundström R, Gustafsson U, Sahlin S, Einarsson C, Trauner M. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 2005; 129: 476–485

Matos A, Bernardes J, Ayres-de-Campos D, Patrício B. Antepartum fetal cerebral hemorrhage not predicted by current surveillance methods in cholestasis of pregnancy. Obstet Gynecol 1997; 89: 803–804

Mazzella G, Rizzo N, Azzaroli F, Simoni P, Bovicelli L, Miracolo A, Simonazzi G, Colecchia A, Nigro G, Mwangemi C, Festi D, Roda E. Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: effects on primary bile acids in babies and mothers. Hepatology 2001; 33: 504–508

Medina Lomelí JM, Medina Castro N. [Intrahepatic cholestasis of pregnancy, an unpredictable fetal risk: report of a case and review of the literature] Ginecol Obstet Mex 2000; 68: 486–488

Meier Y, Zodan T, Lang C, Zimmermann R, Kullak-Ublick GA, Meier PJ, Stieger B, Pauli-Magnus C. Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. World J Gastroenterol 2008; 14: 38–45

Meng LJ, Reyes H, Palma J, Hernandez I, Ribalta J, Sjövall J. Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy. J Hepatol 1997; 27: 346–357

Meng LJ, Reyes H, Axelson M, Palma J, Hernandez I, Ribalta J, Sjövall J. Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy. Hepatology 1997; 26: 1573–1579

Milkiewicz P, Gallagher R, Chambers J, Eggington E, Weaver J, Elias E. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol 2003; 18: 1283–1286

Miller PW, Coen RW, Benirschke K. Dating the time interval from meconium passage to birth. Obstet Gynecol 1985; 66: 459–462

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